showed that glucocorticoid treatment blocked the effects of GSIs in the intestine while enhancing the anti-leukemic and lymphoid effects 30. for all those effects of GSIs in intestinal crypts and adenomas; Notch has no unique function in intestinal progenitors and malignancy cells other than to regulate ATOH1 expression. Reducing ATOH1 activity might mitigate intestinal toxicity … Continue reading showed that glucocorticoid treatment blocked the effects of GSIs in the intestine while enhancing the anti-leukemic and lymphoid effects 30